- Methylphenidate (Ritalin®) is a central nervous system stimulent. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
ketone reduction
benzylic hydroxylation
ortho-aromatic hydroxylation
para-aromatic hydroxylation
ester hydrolysis
- Ticlopidine is an oral platelet-aggregation inhibitror. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
benzylic hydroxylation resulting in N-dealkylation
aromatic hydroxylation on the thiophene ring
N-oxide formation
aromatic hydroxylation on the benzene ring
S-oxidation
- Glybride is an oral hypoglycemic agent. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
O-demethylation
N-oxide formation
benzylic hydroxylation
amide hydrolysis
O-dealkylation
- Raloxifene is an estrogen receptor modulator. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
sulfoxide formation
glucuronidation
ketone reduction
aryl sulfate formation
S-dealkylation
- Clomiphene is a non-steroidal fertilty agent. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
aromatic hydroxylation
epoxidation followed by hydrolysis to form a dihydrodiol
benzylic hydroxylation
omega-1 hydroxylation resulting in N-deethylation
epoxidation
- Methimazole is an oral antithyroid agent. All fo the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
epoxidation
N-demethylation
desulfuration (i.e., S becomes an O)
N-oxide formation
aryl sulfate formation
- Mycophenolate mefexil is an immunosuppresssive prodrug. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
O-dealkylation
ester hydrolysis resulting in N-dealkylation of the morpholine ring (i.e., the ring on the lower left side).
N-dealkylation
ester hydrolysis
oxidation of phenol to carboxylic acid
- Lansoprazole is an oral antiulcer agent. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
N-demethylation
sulfone formation
benzylic hydroxylation
O-dealkylation
oxidation of the benzlic hydroxylation product to yield an acid
- Pivampicillin is an orally active prodrug of the antibiotic ampicillin. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
aromatic hydroxylation
sulfone formation
amide hydrolysis
ester hydrolysis
omega-1 hydroxylation
- Chloramphenicol is an antibiotic. All of the following metabolic reactions for this drug are logical EXCEPT:
Your answer:
benzylic hydroxylation
glucuronidation
oxidation of a primary alcohol to an acid
aromatic hydroxylation
amide hydrolysis